8.7 Cancers of the Cervix and Uterus


Killing Cancer Cells

BCPO (β-caryophyllene oxide) is cytotoxic against cervical cancer cells[Jun_2011][Ambrož_2015]. BCPO has also improved the cytotoxicity of doxorubicin for cancer cells while decreasing its toxicity for normal cells[Ambrož_2015]. 

Linalool is cytotoxic against cervical cancer cells[Chern_2007][Chang_2015]. So are α-terpineol, eucalyptol, and 4-terpineol[Anti_2014]. The flavonoid apigenin induces apoptosis and cell cycle arrest against some forms of cervical cancer cells[Zhen_2005].

Preventing Angiogenesis

β-Eudesmol has inhibited angiogenesis in human cervical cancer cells[Ma_2008]. 

Inhibiting Invasion and Metastasis

CBD inhibits invasion and metastasis in human cervical cancer[Ramer_2009][Ramer_2010][Ramer_2011].

Apigenin inhibits the motility and invasiveness of cervical cancer cells[Czyz_2005].


Jun_2011. Cytotoxic Activity of β-Caryophyllene Oxide Isolated from
Jeju Guava (Psidium cattleianum Sabine) Leaf. Full text. Jun N J, Mosaddik A, Moon J Y, et al. Records of natural products. Published 2011.

Ambrož_2015. The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells. Full text. Ambrož M, Boušová I, Skarka A, et al. Molecules. Online 2015 August 21.

Chern_2007. Chemopreventive effects of minor dietary constituents in common foods on human cancer cells. Abstract. Cherng J-M, Shieh D-E, Chiang W, et al. Bioscience, biotechnology, and biochemistry. Published 2007 June.

Chang_2015. Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs. Full text. Chang M-Y, Shieh D-E, Chen C-C, et al. International journal of molecular sciences. Online 2015 November 26.

Anti_2014. Antitumor Activity of Monoterpenes Found in Essential Oils [literature review]. Full text. Sobral M V, Xavier A L, Lima T C, de Sousa D P. TheScientificWorldJournal. Online 2014 October 14.

Zhen_2005. Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. Abstract. Zheng P-W, Chiang L-C, Lin C-C. Life Sciences. 2005 February 4.

Ma_2008. Beta-eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferation. Abstract. Ma E-L, Li Y-C, Tsuneki H, et al. Journal of Asian natural products research. Published January-February 2008.

 Ramer_2009. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Abstract. Ramer R, Merkord J, Rohde H, Hinz B. Biochemical pharmacology. Online 2009 November 13.

Ramer_2011. Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. Abstract. Ramer R, Bublitz K, Freimuth N, et al. FASEB journal. Online 2011 December 23.

Ramer_2010. Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Abstract. Ramer J, Rohde A, Merkord J, et al. Pharmaceutical research. Online 2010 July 29.

Czyz_2005. Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. Abstract. Czyz J, Madeja Z, Irmer U, et al. International journal of cancer. Published 2005 March 10.