8.16 Other Cancers


Thyroid Cancer. Apigenin promotes apoptosis in thyroid cancer cells[Kim_2015][Yin_1999].

Bone Cancer. Linalool has been shown to be cytotoxic against bone cancer cells (Osteosarcoma Epithelial Cells)[Sobral_2014].

Fibrosarcoma is a highly metastatic form of bone cancer that expresses the cytokine TNF-α. A form of this cancer is found in mice. When mice with the cancer were treated with mouse-derived TNF-α, metastatic tumors sprang up more quickly. But when TNF-α was neutralized, the rate of new metastatic tumor creation slowed down[Orosz_1993]. See Taming Inflammatory Cytokines

Neuroblastoma is a childhood cancer originating in the sympathetic nervous system. CBD reduces the invasiveness of treated tumor cells and triggers apoptosis[Fisher_2016]. Terpinolene prevents cell proliferation in mouse neuroblastoma[Aydin_2013]. BCP and BCPO also induce apoptosis in neuroblastoma cells[Sain_2014].

Cancers in the region of the kidneys. Linalool is cytotoxic against renal cancers [Loizzo_2008][Sobral_2014].

Metastatic Testicular Cancer. CBD helps repair cisplatin-induced liver damage in mice[Pan_2008]. Cisplatin is used as a treatment for metastatic testicular cancer and for metastatic bladder cancer after other treatment strategies have failed[Cancer_2020].

Thymus cancer. THC induces apoptosis[McKallip_2002].

Spleen cancer. THC induces apoptosis[McKallip_2002].


Kim_2015. Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. Abstract. Kim S H, Kang J G, Kim C S, et al. Anticancer research. Published 2015 December.

Yin_1999. Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). Abstract. Yin F, Giuliano A E, Van Herle A J. Anticancer research. Published 1999 September-October.

Sobral_2014. 1.29\. Linalool [in Antitumor Activity of Monoterpenes Found in Essential Oils]. Article section. Sobral M V, Xavier A L, Lima T C, de Sousa D P. ScientificWorldJournal. Published 2014 October 14.

Orosz_1993. Enhancement of experimental metastasis by tumor necrosis factor. Abstract, full text. Orosz P, Echtenacher B, Falk W, et al. Journal of experimental medicine. Published 1993 May 1.

Fisher_2016. In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma. Full text. Fisher T, PhD; Golan H, MD; Schiby G, MD; et al. Current oncology. Online 2016 March 16.

Aydin_2013. Anticancer and antioxidant properties of terpinolene in rat brain cells. Abstract. Aydin E, Türkez H, Taşdemir S. Arhiv za higijenu rada i toksikologiju. Published 2013 September.

Sain_2014. Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells. Abstract. Sain S, Naoghare P K, Devi S S, et al. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. Published 2014 March.

Loizzo_2008. Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. Full text. Loizzo M R, Tundis R, Menichini F, et al. Cell proliferation. Published 2008 December.

Pan_2008. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. Full text. Pan H, Mukhopadhyay P, Rajesh M, et al. The Journal of pharmacology and experimental therapeutics. Online 2008 December 12.

Cancer_2020. Cisplatin. Article. Unattributed. cancer.gov. Updated 2020 October 7.

McKallip_2002. Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. Abstract. McKallip R J, Lombard C, Martin B R, et al. The Journal of pharmacology and experimental therapeutics. Published 2002 August.